Geographical sequence variation in the Leishmania major virulence factor P46
نویسندگان
چکیده
منابع مشابه
Sequence Analysis of HSP70 Gene of Leishmania major and Leishmania tropica in Chabahar and Mashhad
ABSTRACT Background and Objective: Cutaneous leishmaniasis is a parasitic disease and a health problem in different parts of Iran, especially two cities of Mashhad and Chabahar. Due to morphological similarities of most Leishmania species and difference in reservoirs of L. major and L. tropica, it is necessary to determine the parasite speci...
متن کاملLipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major.
Protozoan parasites of the genus Leishmania undergo a complex life cycle involving transmission by biting sand flies and replication within mammalian macrophage phagolysosomes. A major component of the Leishmania surface coat is the glycosylphosphatidylinositol (GPI)-anchored polysaccharide called lipophosphoglycan (LPG). LPG has been proposed to play many roles in the infectious cycle, includi...
متن کاملRegulated expression of the Leishmania major surface virulence factor lipophosphoglycan using conditionally destabilized fusion proteins.
Surface glycoconjugates play important roles in the infectious cycle of Leishmania major, including the abundant lipophosphoglycan (LPG) implicated in parasite survival in the sand fly vector and the initial stages of establishment in the mammalian host macrophage. We describe a system for inducible expression of LPG, applying a novel protein-based system that allows controlled degradation of a...
متن کاملIntraspecific Variation in Leishmania major Isolated from Different Forms of Zoonotic Cutaneous Leishmaniasis
Background: Zoonotic cutaneous leishmaniasis (ZCL) is a polymorphic disease which may show various clinical manifestations. Although genetic variability of the parasite is suggested to be one of the factors influencing clinical manifestations in leishmaniasis, no data exist regarding genetic polymorphism of Leishmania major. Therefore, determination of genetic variation within the species of L....
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Several approaches have been previously used to elucidate the genetic basis of Leishmania virulence. In general, they were based on laboratory Leishmania clones genetically modified or grown in the presence of selecting agents. In a previous study, we demonstrated that Leishmania major freshly isolated from human cutaneous lesions showed significant differences in the severity of the experiment...
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ژورنال
عنوان ژورنال: Infection, Genetics and Evolution
سال: 2015
ISSN: 1567-1348
DOI: 10.1016/j.meegid.2014.12.029